Version 5.4
Homo sapiens Gene: PUS3
Summary
InnateDB Gene IDBG-75686.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PUS3
Gene Name pseudouridylate synthase 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110060
Encoded Proteins
IDBP-75688
pseudouridylate synthase 3
IDBP-602091
pseudouridylate synthase 3
IDBP-585752
pseudouridylate synthase 3
IDBP-583508
pseudouridylate synthase 3
IDBP-812890
pseudouridylate synthase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the formation of tRNA pseudouridine from tRNA uridine at position 39 in the anticodon stem and loop of transfer RNAs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:125893485-125903221
Strand Reverse strand
Band q24.2
Transcripts
ENST00000227474 ENSP00000227474
ENST00000530811 ENSP00000432386
ENST00000534158 ENSP00000432272
ENST00000529801 ENSP00000437077
ENST00000613398 ENSP00000481536
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
Biological Process
GO:0001522 pseudouridine synthesis
GO:0009451 RNA modification
GO:0031119 tRNA pseudouridine synthesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032103
View Gene Order
ENSBTAG00000014339
Not yet available
Cross-References
SwissProt
TrEMBL E9PNY6 E9PRI9
UniProt Splice Variant
Entrez Gene 83480
UniGene Hs.660922
RefSeq XM_005271688 NM_001271985 NM_031307 XM_005271687
HUGO HGNC:25461
OMIM
CCDS CCDS73411 CCDS8466
HPRD 15195
IMGT
EMBL AP000842
GenPept
RNA Seq Atlas 83480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca