Version 5.4
Homo sapiens Gene: NFE2L2
Summary
InnateDB Gene IDBG-75863.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFE2L2
Gene Name nuclear factor (erythroid-derived 2)-like 2
Synonyms NRF2
Species Homo sapiens
Ensembl Gene ENSG00000116044
Encoded Proteins
IDBP-236189
nuclear factor (erythroid-derived 2)-like 2
IDBP-236191
nuclear factor (erythroid-derived 2)-like 2
IDBP-387755
nuclear factor (erythroid-derived 2)-like 2
IDBP-387756
nuclear factor (erythroid-derived 2)-like 2
IDBP-387757
nuclear factor (erythroid-derived 2)-like 2
IDBP-387759
nuclear factor (erythroid-derived 2)-like 2
IDBP-387760
nuclear factor (erythroid-derived 2)-like 2
IDBP-387761
nuclear factor (erythroid-derived 2)-like 2
IDBP-387763
nuclear factor (erythroid-derived 2)-like 2
IDBP-755533
IDBP-755648
IDBP-755440
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21220332
NFE2L2 plays an important role in TLR4-mediated autophagy. NFE2L2 is activated by reactive oxygen species-MAPK14 axis-dependent TLR4 signalling, and induces the accumulation of SQSTM1 and aggresome-like induced structures.
InnateDB Annotation from Orthologs
Summary
PMID 21220332
[Mus musculus] Nfe2l2 plays an important role in Tlr4-mediated autophagy. Nfe2l2 is activated by reactive oxygen species-Mapk14 axis-dependent Tlr4 signaling, and induces the accumulation of Sqstm1 and aggresome-like induced structures.
PMID 24011591
[Mus musculus] Phosphorylation of Sqstm1 (p62) activates the Keap1-Nrf2 pathway during selective autophagy
Entrez Gene
Summary This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:177227595-177392697
Strand Reverse strand
Band q31.2
Transcripts
ENST00000397063 ENSP00000380253
ENST00000397062 ENSP00000380252
ENST00000458603 ENSP00000416308
ENST00000446151 ENSP00000411575
ENST00000449627 ENSP00000391590
ENST00000448782 ENSP00000400073
ENST00000430047 ENSP00000391291
ENST00000421929 ENSP00000412191
ENST00000423513 ENSP00000410015
ENST00000464747 ENSP00000467401
ENST00000477534
ENST00000462023
ENST00000586532 ENSP00000464920
ENST00000588123 ENSP00000468089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 89 [view]
Protein-Protein 82 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001221 transcription cofactor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030194 positive regulation of blood coagulation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034599 cellular response to oxidative stress
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045995 regulation of embryonic development
GO:0060548 negative regulation of cell death
GO:0070301 cellular response to hydrogen peroxide
GO:0071356 cellular response to tumor necrosis factor
GO:0071499 cellular response to laminar fluid shear stress
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000121 regulation of removal of superoxide radicals
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015839
View Gene Order
ENSBTAG00000019255
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q16236
TrEMBL C9J0Y1 C9J1A8 K7ER33
UniProt Splice Variant
Entrez Gene 4780
UniGene Hs.155396 Hs.691940 Hs.741832
RefSeq NM_001145412 NM_001145413 NM_006164
HUGO HGNC:7782
OMIM 600492
CCDS CCDS46457 CCDS42782 CCDS46458
HPRD 02732
IMGT
EMBL AB208786 AC019080 AC079305 AK304555 AK314816 AL135266 BC011558 CH471058 S74017
GenPept AAB32188 AAH11558 AAY14710 BAD92023 BAG37339 BAG65350 EAX11062
RNA Seq Atlas 4780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca