Version 5.4
Homo sapiens Gene: DDX50
Summary
InnateDB Gene IDBG-76203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX50
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000107625
Encoded Proteins
IDBP-76205
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
IDBP-810991
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
IDBP-810992
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
IDBP-810995
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
IDBP-811002
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:68901278-68946847
Strand Forward strand
Band q22.1
Transcripts
ENST00000373585 ENSP00000362687
ENST00000483593 ENSP00000474785
ENST00000471475 ENSP00000474314
ENST00000460470
ENST00000466265
ENST00000612682 ENSP00000479312
ENST00000610822 ENSP00000479336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020076
View Gene Order
ENSBTAG00000033413
Not yet available
Cross-References
SwissProt
TrEMBL S4R3V4
UniProt Splice Variant
Entrez Gene 79009
UniGene
RefSeq NM_024045 XM_005270148
HUGO HGNC:17906
OMIM 610373
CCDS CCDS7283
HPRD
IMGT
EMBL AL359844
GenPept
RNA Seq Atlas 79009

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca