InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYBL2

Summary

InnateDB Gene

IDBG-76209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYBL2

Gene Name

v-myb myeloblastosis viral oncogene homolog (avian)-like 2

Synonyms

B-MYB; BMYB

Species

Homo sapiens

Ensembl Gene

ENSG00000101057

Encoded Proteins

IDBP-76211

v-myb myeloblastosis viral oncogene homolog (avian)-like 2

IDBP-236610

v-myb myeloblastosis viral oncogene homolog (avian)-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:43667019-43716496

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000217026	ENSP00000217026
ENST00000396863	ENSP00000380072

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	53 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051726	regulation of cell cycle
GO:0090307	spindle assembly involved in mitosis