Version 5.4
Homo sapiens Gene: KCNS1
Summary
InnateDB Gene IDBG-77217.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNS1
Gene Name potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
Synonyms KV9.1
Species Homo sapiens
Ensembl Gene ENSG00000124134
Encoded Proteins
IDBP-77219
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
IDBP-603212
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:45092310-45101112
Strand Reverse strand
Band q13.12
Transcripts
ENST00000306117 ENSP00000307694
ENST00000537075 ENSP00000445595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040164
View Gene Order
ENSBTAG00000008870
Not yet available
Pathways
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q96KK3
TrEMBL A2RUL8
UniProt Splice Variant
Entrez Gene 3787
UniGene Hs.117780
RefSeq NM_002251 XM_005260409
HUGO HGNC:6300
OMIM 602905
CCDS CCDS13342
HPRD
IMGT
EMBL AF043473 AK289735 BC075033 BC075034 BC132957 BC132959 BC144234 CH471077 Z93016
GenPept AAC13165 AAH75033 AAH75034 AAI32958 AAI32960 AAI44235 BAF82424 CAB07507 EAW75880
RNA Seq Atlas 3787

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca