InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RBPJL

Summary

InnateDB Gene

IDBG-77456.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBPJL

Gene Name

recombination signal binding protein for immunoglobulin kappa J region-like

Synonyms

RBPSUHL; SUHL

Species

Homo sapiens

Ensembl Gene

ENSG00000124232

Encoded Proteins

IDBP-77458

recombination signal binding protein for immunoglobulin kappa J region-like

IDBP-77460

recombination signal binding protein for immunoglobulin kappa J region-like

IDBP-77462

recombination signal binding protein for immunoglobulin kappa J region-like

IDBP-810018

recombination signal binding protein for immunoglobulin kappa J region-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In mouse, recombining binding protein L (RBP-L) is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signalling pathway transcription factor RBP-J. However, unlike RBP-J, RBP-L does not interact with Notch receptors. RBP-L has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2 (EBNA2). The protein encoded by this gene is similar in sequence to the mouse RPB-L protein and Drosophila suppressor of hairless protein. [provided by RefSeq, Jul 2008]
This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:45306851-45317824

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000343694	ENSP00000341243
ENST00000372741	ENSP00000361826
ENST00000372743	ENSP00000361828
ENST00000464504	ENSP00000483978
ENST00000622729

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000017007

View Gene Order

ENSBTAG00000011283

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04330

Notch signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.248217

RefSeq

NM_001281448 NM_001281449 NM_014276

HUGO

OMIM

CCDS

CCDS13349 CCDS63283 CCDS63284

HPRD

10187

IMGT

EMBL

GenPept

RNA Seq Atlas