Homo sapiens Gene: ARID4A | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-7785.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | ARID4A | ||||||||||||||||||
Gene Name | AT rich interactive domain 4A (RBP1-like) | ||||||||||||||||||
Synonyms | RBBP-1; RBBP1; RBP-1; RBP1 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000032219 | ||||||||||||||||||
Encoded Proteins |
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
AT rich interactive domain 4A (RBP1-like)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 14:58298385-58373887 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q23.1 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.161000 | ||||||||||||||||||
RefSeq | NM_002892 NM_023000 NM_023001 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS45114 CCDS9732 CCDS9733 | ||||||||||||||||||
HPRD | 01575 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||