Version 5.4
Homo sapiens Gene: DDIT4
Summary
InnateDB Gene IDBG-77884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDIT4
Gene Name DNA-damage-inducible transcript 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168209
Encoded Proteins
IDBP-77886
DNA-damage-inducible transcript 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:72273920-72276036
Strand Forward strand
Band q22.1
Transcripts
ENST00000307365 ENSP00000307305
ENST00000473155
ENST00000471240
ENST00000491934
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0071889 14-3-3 protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0001764 neuron migration
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0009968 negative regulation of signal transduction
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0030182 neuron differentiation
GO:0032007 negative regulation of TOR signaling
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043241 protein complex disassembly
GO:0045820 negative regulation of glycolytic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051607 defense response to virus
GO:0072593 reactive oxygen species metabolic process
GO:1901216 positive regulation of neuron death
GO:1902532 negative regulation of intracellular signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020108
View Gene Order
ENSBTAG00000000163
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04150
mTOR signaling pathway pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.723254 Hs.737859 Hs.741387
RefSeq NM_019058
HUGO
OMIM
CCDS CCDS7315
HPRD 09662
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca