InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P4HA1

Summary

InnateDB Gene

IDBG-78057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4HA1

Gene Name

prolyl 4-hydroxylase, alpha polypeptide I

Synonyms

P4HA

Species

Homo sapiens

Ensembl Gene

ENSG00000122884

Encoded Proteins

IDBP-78059

prolyl 4-hydroxylase, alpha polypeptide I

IDBP-78061

prolyl 4-hydroxylase, alpha polypeptide I

IDBP-78063

prolyl 4-hydroxylase, alpha polypeptide I

IDBP-240664

prolyl 4-hydroxylase, alpha polypeptide I

IDBP-379620

prolyl 4-hydroxylase, alpha polypeptide I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:73007217-73096974

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000307116	ENSP00000307318
ENST00000373008	ENSP00000362099
ENST00000263556	ENSP00000263556
ENST00000394890	ENSP00000378353
ENST00000440381	ENSP00000414464
ENST00000464310

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030199	collagen fibril organization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0016222	procollagen-proline 4-dioxygenase complex
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019916

View Gene Order

ENSBTAG00000032996

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00330

Arginine and proline metabolism pathway

INOH

INOH website

Arginine Proline metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000917 NM_001017962 NM_001142595 NM_001142596

HUGO

OMIM

CCDS

CCDS41537 CCDS44432 CCDS7320

HPRD

08901

IMGT

EMBL

GenPept

RNA Seq Atlas