Version 5.4
Homo sapiens Gene: TRIM14
Summary
InnateDB Gene IDBG-78146.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM14
Gene Name tripartite motif containing 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106785
Encoded Proteins
IDBP-78148
tripartite motif containing 14
IDBP-78156
tripartite motif containing 14
IDBP-78158
tripartite motif containing 14
IDBP-481065
tripartite motif containing 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23438823
TRIM14 was identified in a systematic screen for positive regulators of innate immune responses.
PMID 24379373
TRIM14 is a mediator of mitochondrial antiviral immunity facilitating the immune responses mediated by retinoic acid-inducible gene-I-like (RIG-I)-like receptors.
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:98069275-98119212
Strand Reverse strand
Band q22.33
Transcripts
ENST00000375098 ENSP00000364239
ENST00000341469 ENSP00000344208
ENST00000342043 ENSP00000343990
ENST00000478530
ENST00000475147 ENSP00000428805
ENST00000478401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0032897 negative regulation of viral transcription
GO:0045087 innate immune response (InnateDB)
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039853
View Gene Order
ENSBTAG00000024851
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.575631 Hs.712999
RefSeq NM_014788 NM_033219 XM_006717338 XM_006717339
HUGO
OMIM
CCDS CCDS6734
HPRD 05948
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca