Version 5.4
| Homo sapiens Gene: CORO2A | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-78227.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | CORO2A | ||||||||||||||||||||||
| Gene Name | coronin, actin binding protein, 2A | ||||||||||||||||||||||
| Synonyms | CLIPINB; IR10; WDR2 | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000106789 | ||||||||||||||||||||||
| Encoded Proteins |
coronin, actin binding protein, 2A
coronin, actin binding protein, 2A
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
CORO2A mediates transcriptional activation of TLR-responsive genes through a CORO2A-actin-dependent mechanism to remove nuclear receptor co-repressor (NCoR) complexes from the promoters of target genes.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Mus musculus] Coro2a mediates transcriptional activation of TLR-responsive genes through a Coro2a-actin-dependent mechanism to remove nuclear receptor co-repressor (NCoR) complexes from the promoters of target genes.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 9:98120975-98192640 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | q22.33 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||||||
| SwissProt | Q92828 | ||||||||||||||||||||||
| TrEMBL | A0A024R150 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 7464 | ||||||||||||||||||||||
| UniGene | Hs.113094 | ||||||||||||||||||||||
| RefSeq | NM_003389 NM_052820 | ||||||||||||||||||||||
| HUGO | HGNC:2255 | ||||||||||||||||||||||
| OMIM | 602159 | ||||||||||||||||||||||
| CCDS | CCDS6735 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | AL137073 BC000010 BC011690 CH471105 U57057 U57058 | ||||||||||||||||||||||
| GenPept | AAB47807 AAB47808 AAH00010 AAH11690 CAI13893 EAW58879 EAW58880 EAW58881 | ||||||||||||||||||||||
| RNA Seq Atlas | 7464 | ||||||||||||||||||||||