Version 5.4
Homo sapiens Gene: NRIP1
Summary
InnateDB Gene IDBG-788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRIP1
Gene Name nuclear receptor interacting protein 1
Synonyms RIP140
Species Homo sapiens
Ensembl Gene ENSG00000180530
Encoded Proteins
IDBP-790
nuclear receptor interacting protein 1
IDBP-228817
nuclear receptor interacting protein 1
IDBP-228819
nuclear receptor interacting protein 1
IDBP-360690
nuclear receptor interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22388040
NF-κB-mediated degradation of the coactivator NRIP1 (RIP140) regulates inflammatory responses and contributes to endotoxin tolerance. (Demonstrated in mice)
PMID 22388040
NRIP1 is degraded by the NF-kB pathway to inactivate inflammatory gene expression and promotes endotoxin tolerance. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22388040
[Mus musculus] NF-κB-mediated degradation of the coactivator NRIP1 (RIP140) regulates inflammatory responses and contributes to endotoxin tolerance.
PMID 22388040
[Mus musculus] Nrip1 is degraded by the NF-kB pathway to inactivate inflammatory gene expression and promotes endotoxin tolerance.
PMID 26228026
[Mus musculus] Nrip1 plays dual roles in regulating the M1-M2 phenotype switch in macrophages: in the nucleus as an M1 enhancer and in the cytosol as an M2 suppressor.
Entrez Gene
Summary Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:14961235-15065000
Strand Reverse strand
Band q21.1
Transcripts
ENST00000318948 ENSP00000327213
ENST00000400202 ENSP00000383063
ENST00000400199 ENSP00000383060
ENST00000411932 ENSP00000412114
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 80 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
GO:0035257 nuclear hormone receptor binding
GO:0035259 glucocorticoid receptor binding
GO:0042826 histone deacetylase binding
GO:0042974 retinoic acid receptor binding
GO:0046965 retinoid X receptor binding
GO:0050681 androgen receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001543 ovarian follicle rupture
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0019915 lipid storage
GO:0030521 androgen receptor signaling pathway
GO:0030728 ovulation
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0030054 cell junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048490
View Gene Order
ENSBTAG00000047293
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
ar_pathway
Coregulation of Androgen receptor activity
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt P48552
TrEMBL C9J130 N0GW17 N0GWB6
UniProt Splice Variant
Entrez Gene 8204
UniGene Hs.155017 Hs.644641
RefSeq XM_005261063 XM_005261065 XM_005261066 XM_006724054 NM_003489
HUGO HGNC:8001
OMIM 602490
CCDS CCDS13568
HPRD 03927
IMGT
EMBL AF127577 AF248484 AL163207 BC040361 HF584749 HF584750 X84373
GenPept AAF35255 AAF62185 AAH40361 CAA59108 CAB90396 CCQ44046 CCQ44047
RNA Seq Atlas 8204

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca