Version 5.4
Homo sapiens Gene: NCOA5
Summary
InnateDB Gene IDBG-78855.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOA5
Gene Name nuclear receptor coactivator 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124160
Encoded Proteins
IDBP-78857
nuclear receptor coactivator 5
IDBP-78859
nuclear receptor coactivator 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:46060985-46089952
Strand Reverse strand
Band q13.12
Transcripts
ENST00000290231 ENSP00000290231
ENST00000372291 ENSP00000361365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039804
View Gene Order
ENSBTAG00000014186
Not yet available
Cross-References
SwissProt Q9HCD5
TrEMBL Q5JY17
UniProt Splice Variant
Entrez Gene 57727
UniGene Hs.618657 Hs.654991
RefSeq NM_020967 XM_005260474 XM_005260475
HUGO HGNC:15909
OMIM
CCDS CCDS13392
HPRD
IMGT
EMBL AB046857 AF230533 AF470686 AL035662 AL162458 BC140836 BC151133 CH471077
GenPept AAG36793 AAI40837 AAI51134 AAO33457 BAB13463 CAH74052 CAI42972 EAW75765 EAW75769
RNA Seq Atlas 57727

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca