InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HSPA1A

Summary

InnateDB Gene

IDBG-79274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA1A

Gene Name

heat shock 70kDa protein 1A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000204389

Encoded Proteins

IDBP-79278

heat shock 70kDa protein 1A

IDBP-808417

heat shock 70kDa protein 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21448922

HSPA1A is secreted into the extracellular space during exercise-induced stress and increases the intracellular levels of cAMP, which acts as an "intracellular danger signal" to activate neutrophils.

PMID 24257755

Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1.

Entrez Gene

Summary

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:31815464-31817946

Strand

Forward strand

Band

p21.33

Transcripts

ENST00000375651	ENSP00000364802
ENST00000608703	ENSP00000477378

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 199 experimentally validated interaction(s) in this database.

Experimentally validated
Total	199 [view]
Protein-Protein	195 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0031072	heat shock protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042623	ATPase activity, coupled
GO:0044183	protein binding involved in protein folding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006402	mRNA catabolic process
GO:0006986	response to unfolded protein
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0030308	negative regulation of cell growth
GO:0034605	cellular response to heat
GO:0042026	protein refolding
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0060548	negative regulation of cell death
GO:0070370	cellular heat acclimation
GO:0090084	negative regulation of inclusion body assembly
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005814	centriole
GO:0005829	cytosol
GO:0008180	COP9 signalosome
GO:0016234	inclusion body
GO:0016235	aggresome
GO:0016607	nuclear speck
GO:0030529	ribonucleoprotein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

No orthologs found for this gene

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_9

TNFalpha pathway

REACTOME

REACT_25325

AUF1 (hnRNP D0) destabilizes mRNA pathway

REACT_6198

Viral RNP Complexes in the Host Cell Nucleus pathway

REACT_120956

Cellular responses to stress pathway

REACT_6167

Influenza Infection pathway

REACT_200780

Regulation of HSF1-mediated heat shock response pathway

REACT_200624

Attenuation phase pathway

REACT_200775

HSF1-dependent transactivation pathway

REACT_200819

Cellular response to heat stress pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_6145

Influenza Life Cycle pathway

REACT_6296

Export of Viral Ribonucleoproteins from Nucleus pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04612

Antigen processing and presentation pathway

hsa04144

Endocytosis pathway

hsa05020

Prion diseases pathway

hsa03040

Spliceosome pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

foxm1pathway

FOXM1 transcription factor network

Cross-References

SwissProt

P08107

TrEMBL

A8K5I0 V9GZ37

UniProt Splice Variant

Entrez Gene

3304

UniGene

Hs.274402

RefSeq

NM_005345

HUGO

HGNC:5232

OMIM

140550 603012

CCDS

CCDS34414

HPRD

IMGT

EMBL

AF134726 AK291295 AK304652 AL662834 AL671762 AL929592 BA000025 BC002453 BC009322 BC018740 BC057397 BC063507 CH471081 DQ388429 DQ451402 FJ224292 M11717 M24743 M24744 M59828 M59830 X04676 X04677

GenPept

AAA52697 AAA59844 AAA59845 AAA63226 AAA63227 AAD21815 AAD21816 AAH02453 AAH09322 AAH18740 AAH57397 AAH63507 ABD48956 ABD96830 ACI45984 BAB63299 BAB63300 BAF83984 BAG65428 CAA28381 CAA28382 CAI17737 CAI17738 CAI18216 CAI18217 CAI18464 CAI18466 EAX03528 EAX03529

RNA Seq Atlas

3303 3304