Homo sapiens Gene: HSPA1A
Summary
InnateDB Gene IDBG-79274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPA1A
Gene Name heat shock 70kDa protein 1A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204389
Encoded Proteins
heat shock 70kDa protein 1A
heat shock 70kDa protein 1A
Protein Structure
InnateDB Annotation
Summary
HSPA1A is secreted into the extracellular space during exercise-induced stress and increases the intracellular levels of cAMP, which acts as an "intracellular danger signal" to activate neutrophils.
Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1.
Entrez Gene
Summary This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31815464-31817946
Strand Forward strand
Band p21.33
Transcripts
ENST00000375651 ENSP00000364802
ENST00000608703 ENSP00000477378
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 199 experimentally validated interaction(s) in this database.
Experimentally validated
Total 199 [view]
Protein-Protein 195 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0019899 enzyme binding
GO:0031072 heat shock protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0042623 ATPase activity, coupled
GO:0044183 protein binding involved in protein folding
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006200 ATP catabolic process
GO:0006402 mRNA catabolic process
GO:0006986 response to unfolded protein
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0030308 negative regulation of cell growth
GO:0034605 cellular response to heat
GO:0042026 protein refolding
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045648 positive regulation of erythrocyte differentiation
GO:0060548 negative regulation of cell death
GO:0070370 cellular heat acclimation
GO:0090084 negative regulation of inclusion body assembly
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005814 centriole
GO:0005829 cytosol
GO:0008180 COP9 signalosome
GO:0016234 inclusion body
GO:0016235 aggresome
GO:0016607 nuclear speck
GO:0030529 ribonucleoprotein complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
AndrogenReceptor pathway
TNFalpha pathway
REACTOME
Cellular responses to stress pathway
Influenza Infection pathway
Regulation of HSF1-mediated heat shock response pathway
Attenuation phase pathway
Viral RNP Complexes in the Host Cell Nucleus pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Influenza Life Cycle pathway
Export of Viral Ribonucleoproteins from Nucleus pathway
Gene Expression pathway
Disease pathway
KEGG
Spliceosome pathway
MAPK signaling pathway pathway
Protein processing in endoplasmic reticulum pathway
Endocytosis pathway
Antigen processing and presentation pathway
Prion diseases pathway
Toxoplasmosis pathway
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
FOXM1 transcription factor network
Cross-References
SwissProt P08107
TrEMBL A8K5I0 V9GZ37
UniProt Splice Variant
Entrez Gene 3304
UniGene Hs.274402
RefSeq NM_005345
HUGO HGNC:5232
OMIM 140550 603012
CCDS CCDS34414
HPRD 00774
IMGT
EMBL AF134726 AK291295 AK304652 AL662834 AL671762 AL929592 BA000025 BC002453 BC009322 BC018740 BC057397 BC063507 CH471081 DQ388429 DQ451402 FJ224292 M11717 M24743 M24744 M59828 M59830 X04676 X04677
GenPept AAA52697 AAA59844 AAA59845 AAA63226 AAA63227 AAD21815 AAD21816 AAH02453 AAH09322 AAH18740 AAH57397 AAH63507 ABD48956 ABD96830 ACI45984 BAB63299 BAB63300 BAF83984 BAG65428 CAA28381 CAA28382 CAI17737 CAI17738 CAI18216 CAI18217 CAI18464 CAI18466 EAX03528 EAX03529
ImmGen HSPA1A (murine)
RNA Seq Atlas 3303 3304