Homo sapiens Gene: POLR3A
Summary
InnateDB Gene IDBG-79933.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR3A
Gene Name polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Synonyms ADDH; HLD7; hRPC155; RPC1; RPC155;
Species Homo sapiens
Ensembl Gene ENSG00000148606
Encoded Proteins
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:77969251-78029545
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372371 ENSP00000361446
ENST00000472014
ENST00000473588 ENSP00000473389
ENST00000484760
ENST00000616246 ENSP00000483738
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0008270 zinc ion binding
GO:0032549 ribonucleoside binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0006385 transcription elongation from RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0010467 gene expression
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
RNA Polymerase III Transcription Initiation pathway
RNA Polymerase III Transcription Termination pathway
Innate Immune System pathway
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
RNA Polymerase III Chain Elongation pathway
Immune System pathway
RNA Polymerase III Transcription pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Cytosolic sensors of pathogen-associated DNA pathway
Gene Expression pathway
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
RNA polymerase pathway
Cytosolic DNA-sensing pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O14802
TrEMBL Q7Z755 Q8TCW2 Q8TCW3 Q8TCW4
UniProt Splice Variant
Entrez Gene 11128
UniGene Hs.436896 Hs.619499
RefSeq NM_007055 XM_006717597
HUGO HGNC:30074
OMIM 614258
CCDS CCDS7354
HPRD 17879
IMGT
EMBL AF021351 AL512628 AY091459 AY091460 AY091461 AY091462 BC014399 BC041089 CH471083
GenPept AAB86536 AAH14399 AAH41089 AAM12029 AAM12030 AAM12031 AAM12032 CAI16466 EAW54617
ImmGen POLR3A (murine)
RNA Seq Atlas 11128