Homo sapiens Gene: POLR3A

Summary
InnateDB Gene IDBG-79933.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol POLR3A
Gene Name polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Synonyms ADDH; HLD7; hRPC155; RPC1; RPC155
Species Homo sapiens
Ensembl Gene ENSG00000148606
Encoded Proteins
IDBP-79935 polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Entrez Gene
Summary The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10: 79729008-79789303
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372371  ENSP00000361446
ENST00000480092 
ENST00000472014 
ENST00000473588 
ENST00000484760 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein‑Protein  31
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0008270 zinc ion binding
GO:0032549 ribonucleoside binding
Biological Process
GO:0006351 transcription, DNA-dependent
GO:0006383 transcription from RNA polymerase III promoter
GO:0006385 transcription elongation from RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0010467 gene expression
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000025280 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000013259 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_22339 RNA Polymerase III Abortive And Retractive Initiation
REACT_756 RNA Polymerase III Chain Elongation
REACT_347 RNA Polymerase III Transcription Initiation From Type 1 Promoter
REACT_1036 RNA Polymerase III Transcription Initiation From Type 2 Promoter
REACT_571 RNA Polymerase III Transcription Initiation From Type 3 Promoter
REACT_63 RNA Polymerase III Transcription Termination
KEGG
hsa04623  Cytosolic DNA-sensing pathway
hsa01100  Metabolic pathways
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa03020  RNA polymerase
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O14802 
TrEMBL Q8TCW2 Q8TCW3 Q8TCW4
UniProt Splice Variant
Entrez Gene 11128 
UniGene Hs.436896 Hs.619499
RefSeq NM_007055 
HUGO 30074 
OMIM 614258
CCDS CCDS7354 
HPRD 17879
IMGT
EMBL AF021351 AL512628 AY091459 AY091460 AY091461 AY091462 BC041089 CH471083
GenPept AAB86536  AAH41089  AAM12029  AAM12030  AAM12031  AAM12032  CAI16466  EAW54617 
ImmGen POLR3A (murine) 
RNA Seq Atlas 11128