Version 5.4
Homo sapiens Gene: EIF2AK1
Summary
InnateDB Gene IDBG-8016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2AK1
Gene Name eukaryotic translation initiation factor 2-alpha kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000086232
Encoded Proteins
IDBP-8018
eukaryotic translation initiation factor 2-alpha kinase 1
IDBP-363595
eukaryotic translation initiation factor 2-alpha kinase 1
IDBP-363599
eukaryotic translation initiation factor 2-alpha kinase 1
IDBP-363605
eukaryotic translation initiation factor 2-alpha kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:6022244-6059230
Strand Reverse strand
Band p22.1
Transcripts
ENST00000199389 ENSP00000199389
ENST00000422786 ENSP00000392734
ENST00000431744 ENSP00000392459
ENST00000446699 ENSP00000397590
ENST00000490523
ENST00000495565
ENST00000474029
ENST00000470168
ENST00000463213
ENST00000461493
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0008285 negative regulation of cell proliferation
GO:0009605 response to external stimulus
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0045993 negative regulation of translational initiation by iron
GO:0046501 protoporphyrinogen IX metabolic process
GO:0046777 protein autophosphorylation
GO:0046984 regulation of hemoglobin biosynthetic process
GO:0046986 negative regulation of hemoglobin biosynthetic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029613
View Gene Order
ENSBTAG00000007370
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520205 Hs.612945 Hs.741538
RefSeq NM_001134335 NM_014413
HUGO
OMIM
CCDS CCDS5345
HPRD 10684
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca