InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TXN

Summary

InnateDB Gene

IDBG-80361.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXN

Gene Name

thioredoxin

Synonyms

TRDX; TRX; TRX1

Species

Homo sapiens

Ensembl Gene

ENSG00000136810

Encoded Proteins

IDBP-80363

thioredoxin

IDBP-80365

thioredoxin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:110243811-110256640

Strand

Reverse strand

Band

q31.3

Transcripts

ENST00000374517	ENSP00000363641
ENST00000374515	ENSP00000363639
ENST00000487892

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.

Experimentally validated
Total	75 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0015037	peptide disulfide oxidoreductase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006662	glycerol ether metabolic process
GO:0006928	cellular component movement
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0009314	response to radiation
GO:0015949	nucleobase-containing small molecule interconversion
GO:0033158	regulation of protein import into nucleus, translocation
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043388	positive regulation of DNA binding
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0045454	cell redox homeostasis
GO:0046826	negative regulation of protein export from nucleus
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome