Version 5.4
Homo sapiens Gene: RNF5
Summary
InnateDB Gene IDBG-80442.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF5
Gene Name ring finger protein 5, E3 ubiquitin protein ligase
Synonyms RING5; RMA1
Species Homo sapiens
Ensembl Gene ENSG00000204308
Encoded Proteins
IDBP-80444
ring finger protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19285439
RNF5 negatively regulates virus-triggered signaling by targeting TMEM173, an adaptor protein that links virus-sensing receptors to IRF3 activation, for ubiquitination and degradation at the mitochondria.
Entrez Gene
Summary The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32178354-32180793
Strand Forward strand
Band p21.32
Transcripts
ENST00000375094 ENSP00000364235
ENST00000487940
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 39 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009617 response to bacterium
GO:0010507 negative regulation of autophagy
GO:0016567 protein ubiquitination
GO:0031648 protein destabilization
GO:0044257 cellular protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0071712 ER-associated misfolded protein catabolic process
GO:2000785 regulation of autophagic vacuole assembly
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015478
View Gene Order
ENSBTAG00000025413
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.644711
RefSeq NM_006913
HUGO
OMIM
CCDS CCDS4745
HPRD 04057
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca