InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NRG3

Summary

InnateDB Gene

IDBG-80642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRG3

Gene Name

neuregulin 3

Synonyms

HRG3; pro-NRG3

Species

Homo sapiens

Ensembl Gene

ENSG00000185737

Encoded Proteins

IDBP-80644

neuregulin 3

IDBP-80648

neuregulin 3

IDBP-295340

neuregulin 3

IDBP-295326

neuregulin 3

IDBP-593230

neuregulin 3

IDBP-585312

neuregulin 3

IDBP-591994

neuregulin 3

IDBP-588888

neuregulin 3

IDBP-812977

neuregulin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:81875314-82987179

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000372142	ENSP00000361215
ENST00000372141	ENSP00000361214
ENST00000404547	ENSP00000384796
ENST00000404576	ENSP00000385804
ENST00000555784	ENSP00000451858
ENST00000556918	ENSP00000451376
ENST00000545131	ENSP00000441201
ENST00000537893	ENSP00000440377
ENST00000602794	ENSP00000473669

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007389	pattern specification process
GO:0009790	embryo development
GO:0030879	mammary gland development
GO:0035556	intracellular signal transduction
GO:0060596	mammary placode formation