Version 5.4
Homo sapiens Gene: FAS
Summary
InnateDB Gene IDBG-81669.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAS
Gene Name Fas (TNF receptor superfamily, member 6)
Synonyms ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
Species Homo sapiens
Ensembl Gene ENSG00000026103
Encoded Proteins
IDBP-81673
Fas (TNF receptor superfamily, member 6)
IDBP-81675
Fas (TNF receptor superfamily, member 6)
IDBP-81677
Fas (TNF receptor superfamily, member 6)
IDBP-81685
Fas (TNF receptor superfamily, member 6)
IDBP-482023
Fas (TNF receptor superfamily, member 6)
IDBP-484287
Fas (TNF receptor superfamily, member 6)
IDBP-482044
Fas (TNF receptor superfamily, member 6)
IDBP-474762
Fas (TNF receptor superfamily, member 6)
IDBP-476300
Fas (TNF receptor superfamily, member 6)
IDBP-807191
Fas cell surface death receptor
IDBP-807194
Fas cell surface death receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:88990531-89015785
Strand Forward strand
Band q23.31
Transcripts
ENST00000355740 ENSP00000347979
ENST00000357339 ENSP00000349896
ENST00000355279 ENSP00000347426
ENST00000313771
ENST00000352159 ENSP00000345601
ENST00000371857
ENST00000484444 ENSP00000420975
ENST00000494410 ENSP00000423755
ENST00000479522 ENSP00000424113
ENST00000488877 ENSP00000425159
ENST00000492756 ENSP00000422453
ENST00000460510
ENST00000477270
ENST00000466081
ENST00000494799
ENST00000487314
ENST00000612663 ENSP00000477997
ENST00000615406 ENSP00000484575
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 123 [view]
Protein-Protein 109 [view]
Protein-DNA 10 [view]
Protein-RNA 3 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0002377 immunoglobulin production
GO:0003014 renal system process
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006924 activation-induced cell death of T cells
GO:0006925 inflammatory cell apoptotic process
GO:0006927 transformed cell apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009636 response to toxic substance
GO:0010467 gene expression
GO:0019724 B cell mediated immunity
GO:0032464 positive regulation of protein homooligomerization
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045060 negative thymic T cell selection
GO:0045619 regulation of lymphocyte differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0048536 spleen development
GO:0050869 negative regulation of B cell activation
GO:0051260 protein homooligomerization
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0071285 cellular response to lithium ion
GO:0071455 cellular response to hyperoxia
GO:0097049 motor neuron apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097527 necroptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024778
View Gene Order
ENSBTAG00000010785
Not yet available
Pathways
NETPATH
REACTOME
REACT_900
FasL/ CD95L signaling pathway
REACT_1059
Extrinsic Pathway for Apoptosis pathway
REACT_578
Apoptosis pathway
REACT_1619
Death Receptor Signalling pathway
KEGG
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05010
Alzheimer's disease pathway
hsa04940
Type I diabetes mellitus pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04115
p53 signaling pathway pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05332
Graft-versus-host disease pathway
hsa05200
Pathways in cancer pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05143
African trypanosomiasis pathway
INOH
INOH website
Fas signaling pathway pathway
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
p53downstreampathway
Direct p53 effectors
p73pathway
p73 transcription factor network
tap63pathway
Validated transcriptional targets of TAp63 isoforms
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623093
RefSeq NM_000043 NM_152871 NM_152872 XM_006717819
HUGO
OMIM
CCDS CCDS7393 CCDS7394 CCDS7395
HPRD 00609
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca