Version 5.4
Homo sapiens Gene: CYP26C1
Summary
InnateDB Gene IDBG-82642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP26C1
Gene Name cytochrome P450, family 26, subfamily C, polypeptide 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187553
Encoded Proteins
IDBP-82644
cytochrome P450, family 26, subfamily C, polypeptide 1
IDBP-811806
cytochrome P450, family 26, subfamily C, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:93060808-93069536
Strand Forward strand
Band q23.33
Transcripts
ENST00000285949 ENSP00000285949
ENST00000624358 ENSP00000485098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001972 retinoic acid binding
GO:0005506 iron ion binding
GO:0008401 retinoic acid 4-hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0006766 vitamin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007417 central nervous system development
GO:0009952 anterior/posterior pattern specification
GO:0014032 neural crest cell development
GO:0034653 retinoic acid catabolic process
GO:0044281 small molecule metabolic process
GO:0048284 organelle fusion
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062432
View Gene Order
ENSBTAG00000039973
Not yet available
Pathways
NETPATH
REACTOME
REACT_13450
Vitamins pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00830
Retinol metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_183374
HUGO
OMIM
CCDS CCDS7425
HPRD 12230
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca