InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HTR2C

Summary

InnateDB Gene

IDBG-82920.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR2C

Gene Name

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Synonyms

5-HT2C; 5-HTR2C; 5HTR2C; HTR1C

Species

Homo sapiens

Ensembl Gene

ENSG00000147246

Encoded Proteins

IDBP-82922

5-hydroxytryptamine (serotonin) receptor 2C

IDBP-82924

5-hydroxytryptamine (serotonin) receptor 2C

IDBP-82926

5-hydroxytryptamine (serotonin) receptor 2C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:114584078-114910061

Strand

Forward strand

Band

q23

Transcripts

ENST00000276198	ENSP00000276198
ENST00000371951	ENSP00000361019
ENST00000371950	ENSP00000361018

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001587	Gq/11-coupled serotonin receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0008144	drug binding
GO:0051378	serotonin binding
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Biological Process

GO:0001662	behavioral fear response
GO:0006182	cGMP biosynthetic process
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007208	phospholipase C-activating serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007626	locomotory behavior
GO:0007631	feeding behavior
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0031644	regulation of neurological system process
GO:0032098	regulation of appetite
GO:0042493	response to drug
GO:0043397	regulation of corticotropin-releasing hormone secretion
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade