Version 5.4
Homo sapiens Gene: HELLS
Summary
InnateDB Gene IDBG-83141.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HELLS
Gene Name helicase, lymphoid-specific
Synonyms LSH; PASG; SMARCA6
Species Homo sapiens
Ensembl Gene ENSG00000119969
Encoded Proteins
IDBP-83143
helicase, lymphoid-specific
IDBP-83145
helicase, lymphoid-specific
IDBP-83147
helicase, lymphoid-specific
IDBP-83149
helicase, lymphoid-specific
IDBP-242335
helicase, lymphoid-specific
IDBP-242339
helicase, lymphoid-specific
IDBP-382994
helicase, lymphoid-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:94501434-94613905
Strand Forward strand
Band q23.33
Transcripts
ENST00000348459 ENSP00000239027
ENST00000371332 ENSP00000360383
ENST00000371327 ENSP00000360378
ENST00000239026 ENSP00000239026
ENST00000394045 ENSP00000377609
ENST00000394036 ENSP00000377601
ENST00000419900 ENSP00000409945
ENST00000462057
ENST00000466552
ENST00000464030
ENST00000475263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0001655 urogenital system development
GO:0006306 DNA methylation
GO:0006342 chromatin silencing
GO:0006346 methylation-dependent chromatin silencing
GO:0006351 transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0007275 multicellular organismal development
GO:0008152 metabolic process
GO:0010216 maintenance of DNA methylation
GO:0031508 centromeric heterochromatin assembly
GO:0043066 negative regulation of apoptotic process
GO:0046651 lymphocyte proliferation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005721 centromeric heterochromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025001
View Gene Order
ENSBTAG00000005979
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt Q9NRZ9
TrEMBL B1ALG6
UniProt Splice Variant
Entrez Gene 3070
UniGene Hs.463677 Hs.598498 Hs.599954 Hs.655830
RefSeq NM_001289067 NM_001289068 NM_001289069 NM_001289070 NM_001289071 NM_001289072 NM_001289073 NM_001289074 NM_001289075 NM_018063
HUGO HGNC:4861
OMIM 603946
CCDS CCDS73162 CCDS73163 CCDS73164 CCDS73165 CCDS7434
HPRD 07232
IMGT
EMBL AB074174 AB102717 AB102718 AB102719 AB102720 AB102721 AB102722 AB113249 AF155827 AK314485 AL138759 AY007108 BC015477 BC029381 BC030963 BC031004 BX538033 CH471066
GenPept AAF82262 AAG01987 AAH15477 AAH29381 AAH30963 AAH31004 BAD10845 BAD10846 BAD10847 BAD10848 BAD10849 BAD10850 BAD24805 BAE45737 BAG37088 CAD13191 CAD97978 EAW50035
RNA Seq Atlas 3070

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca