InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DGKD

Summary

InnateDB Gene

IDBG-83485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKD

Gene Name

diacylglycerol kinase, delta 130kDa

Synonyms

dgkd-2; DGKdelta

Species

Homo sapiens

Ensembl Gene

ENSG00000077044

Encoded Proteins

IDBP-83487

diacylglycerol kinase, delta 130kDa

IDBP-292886

diacylglycerol kinase, delta 130kDa

IDBP-389380

diacylglycerol kinase, delta 130kDa

IDBP-389381

diacylglycerol kinase, delta 130kDa

IDBP-389382

diacylglycerol kinase, delta 130kDa

IDBP-808362

diacylglycerol kinase, delta 130kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:233354507-233472104

Strand

Forward strand

Band

q37.1

Transcripts

ENST00000264057	ENSP00000264057
ENST00000409813	ENSP00000386455
ENST00000427930	ENSP00000407938
ENST00000447484	ENSP00000395530
ENST00000430834	ENSP00000390970
ENST00000489613
ENST00000472732
ENST00000490764
ENST00000474488
ENST00000480535
ENST00000465569
ENST00000471764
ENST00000495901
ENST00000622717	ENSP00000479051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019992	diacylglycerol binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0007596	blood coagulation
GO:0010033	response to organic substance
GO:0015031	protein transport
GO:0016049	cell growth
GO:0016310	phosphorylation
GO:0019932	second-messenger-mediated signaling
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0046339	diacylglycerol metabolic process
GO:0051260	protein homooligomerization

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016023	cytoplasmic membrane-bounded vesicle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000070738

View Gene Order

ENSBTAG00000020616

Not yet available

Pathways

NETPATH

REACTOME

REACT_2202

Effects of PIP2 hydrolysis pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_14797

Signaling by GPCR pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_604

Hemostasis pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa00561

Glycerolipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.471675

RefSeq

NM_003648 NM_152879 XM_005246107 XM_005246108 XM_005246109 XM_005246110

HUGO

OMIM

CCDS

CCDS2504 CCDS46546

HPRD

03492

IMGT

EMBL

GenPept

RNA Seq Atlas