Version 5.4
Homo sapiens Gene: UBE2A
Summary
InnateDB Gene IDBG-83741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2A
Gene Name ubiquitin-conjugating enzyme E2A
Synonyms HHR6A; MRXS30; MRXSN; RAD6A; UBC2
Species Homo sapiens
Ensembl Gene ENSG00000077721
Encoded Proteins
IDBP-83745
ubiquitin-conjugating enzyme E2A
IDBP-83747
ubiquitin-conjugating enzyme E2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Jul 2008]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:119574538-119584418
Strand Forward strand
Band q24
Transcripts
ENST00000371569
ENST00000346330 ENSP00000335027
ENST00000371558 ENSP00000360613
ENST00000469205
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001701 in utero embryonic development
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006281 DNA repair
GO:0006301 postreplication repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008284 positive regulation of cell proliferation
GO:0009411 response to UV
GO:0033522 histone H2A ubiquitination
GO:0051865 protein autoubiquitination
GO:0060135 maternal process involved in female pregnancy
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0001741 XY body
GO:0005829 cytosol
GO:0033503 HULC complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000016308
View Gene Order
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt P49459
TrEMBL
UniProt Splice Variant
Entrez Gene 7319
UniGene Hs.379466
RefSeq NM_181762 NM_001282161 NM_003336
HUGO HGNC:12472
OMIM 312180
CCDS CCDS14581 CCDS14580
HPRD 02422
IMGT
EMBL AC004913 AK297696 AK313092 BC010175 CH471161 DQ068065 M74524
GenPept AAA35981 AAH10175 AAY46159 BAG35916 BAG60054 EAW89861 EAW89862 EAW89863
RNA Seq Atlas 7319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca