Version 5.4
Homo sapiens Gene: CLPS
Summary
InnateDB Gene IDBG-84391.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLPS
Gene Name colipase, pancreatic
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137392
Encoded Proteins
IDBP-84393
colipase, pancreatic
IDBP-810859
colipase, pancreatic
IDBP-810860
colipase, pancreatic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:35794982-35797344
Strand Reverse strand
Band p21.31
Transcripts
ENST00000259938 ENSP00000259938
ENST00000622413 ENSP00000482919
ENST00000616014 ENSP00000483589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008047 enzyme activator activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0006629 lipid metabolic process
GO:0007586 digestion
GO:0007603 phototransduction, visible light
GO:0016042 lipid catabolic process
GO:0043085 positive regulation of catalytic activity
GO:0044241 lipid digestion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024225
View Gene Order
ENSBTAG00000016833
Not yet available
Pathways
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_9518
Digestion of dietary lipid pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
KEGG
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5U808
UniProt Splice Variant
Entrez Gene 1208
UniGene
RefSeq NM_001252598 NM_001252597 NM_001832
HUGO HGNC:2085
OMIM 120105
CCDS CCDS75438 CCDS4811 CCDS75437
HPRD
IMGT
EMBL AY780649
GenPept AAV35729
RNA Seq Atlas 1208

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca