Version 5.4
Homo sapiens Gene: APLN
Summary
InnateDB Gene IDBG-85619.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APLN
Gene Name apelin
Synonyms APEL; XNPEP2
Species Homo sapiens
Ensembl Gene ENSG00000171388
Encoded Proteins
IDBP-380699
apelin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:129645809-129654937
Strand Reverse strand
Band q26.1
Transcripts
ENST00000429967 ENSP00000391800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL B2R550 D3DTF8
UniProt Splice Variant
Entrez Gene 8862
UniGene Hs.303084
RefSeq NM_017413
HUGO HGNC:16665
OMIM 300297
CCDS
HPRD
IMGT
EMBL AK312061 AL022162 CH471107
GenPept BAG34997 EAX11828 EAX11829
RNA Seq Atlas 8862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca