Version 5.4
Homo sapiens Gene: GRAP2
Summary
InnateDB Gene IDBG-8576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRAP2
Gene Name GRB2-related adaptor protein 2
Synonyms GADS; GRAP-2; GRB2L; GRBLG; GrbX; Grf40; GRID; GRPL; Mona; P38
Species Homo sapiens
Ensembl Gene ENSG00000100351
Encoded Proteins
IDBP-8578
GRB2-related adaptor protein 2
IDBP-293368
GRB2-related adaptor protein 2
IDBP-377460
GRB2-related adaptor protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:39901082-39973721
Strand Forward strand
Band q13.1
Transcripts
ENST00000344138 ENSP00000339186
ENST00000407075 ENSP00000385607
ENST00000420971 ENSP00000396355
ENST00000478445
ENST00000461082
ENST00000481263
ENST00000460449
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0007267 cell-cell signaling
GO:0009967 positive regulation of signal transduction
GO:0031295 T cell costimulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042351
View Gene Order
ENSBTAG00000015157
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_12526
TCR signaling pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04660
T cell receptor signaling pathway pathway
INOH
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
tcr_pathway
TCR signaling in naïve CD4+ T cells
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
tcrjnkpathway
JNK signaling in the CD4+ TCR pathway
Cross-References
SwissProt O75791
TrEMBL B1AH86 B7Z8E3 Q6FI14
UniProt Splice Variant
Entrez Gene 9402
UniGene Hs.599494
RefSeq NM_001291824 NM_001291825 NM_004810 XM_005261841 XM_006724376
HUGO HGNC:4563
OMIM 604518
CCDS CCDS13999
HPRD
IMGT
EMBL AF042380 AF090456 AF102694 AF121002 AF129476 AF236119 AF236120 AJ011736 AK303280 AK303470 AK312830 AY069959 BC025692 BC026002 CH471095 CR456498 CR536524 Y18051 Z82206
GenPept AAC69273 AAD04926 AAD13027 AAD41782 AAF31758 AAF60319 AAF60320 AAH25692 AAH26002 AAL58573 BAG35685 BAH13929 BAH13969 CAA09757 CAA77021 CAG30384 CAG38761 CAI42713 EAW60356 EAW60359
RNA Seq Atlas 9402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca