Homo sapiens Gene: HPSE2

Summary
InnateDB Gene IDBG-85956.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol HPSE2
Gene Name heparanase 2
Synonyms HPA2; HPR2; UFS; UFS1
Species Homo sapiens
Ensembl Gene ENSG00000172987
Encoded Proteins
IDBP-85958 heparanase 2
IDBP-85960 heparanase 2
IDBP-85962 heparanase 2
IDBP-294888 heparanase 2
Entrez Gene
Summary This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10: 100218875-100995619
Strand Reverse strand
Band q24.2
Transcripts
ENST00000370552  ENSP00000359583
ENST00000370549  ENSP00000359580
ENST00000370546  ENSP00000359577
ENST00000404542  ENSP00000384384
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030305 heparanase activity
GO:0043169 cation binding
GO:0043395 heparan sulfate proteoglycan binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006027 glycosaminoglycan catabolic process
GO:0008150 biological_process
GO:0030203 glycosaminoglycan metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000074852 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
REACT_120752 HS-GAG degradation
KEGG
hsa00531  Glycosaminoglycan degradation
hsa01100  Metabolic pathways
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8WWQ2 
TrEMBL
UniProt Splice Variant
Entrez Gene 60495 
UniGene Hs.500750
RefSeq NM_001166244  NM_001166245  NM_001166246  NM_021828 
HUGO 18374 
OMIM 613469
CCDS CCDS53566  CCDS53567  CCDS53568  CCDS7477 
HPRD 13669
IMGT
EMBL AF282885 AF282886 AF282887 AJ299719 AJ299720 AL139243 AL356220 AL356268 AL445251 AL590036
GenPept AAG23421  AAG23422  AAG23423  CAC82491  CAC82492  CAH70448  CAH70449  CAH70450  CAH73137  CAH73138  CAH73139  CAI14146  CAI14147  CAI14148  CAI16472  CAI16473  CAI16474  CAI17160  CAI17161  CAI17162 
ImmGen HPSE2 (murine) 
RNA Seq Atlas 60495