Homo sapiens Gene: HPSE2
Summary
InnateDB Gene IDBG-85956.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol HPSE2
Gene Name heparanase 2
Synonyms HPA2; HPR2; UFS; UFS1;
Species Homo sapiens
Ensembl Gene ENSG00000172987
Encoded Proteins
heparanase 2
heparanase 2
heparanase 2
heparanase 2
Protein Structure
Entrez Gene
Summary This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:100218875-100995619
Strand Reverse strand
Band q24.2
Transcripts
ENST00000370552 ENSP00000359583
ENST00000370549 ENSP00000359580
ENST00000370546 ENSP00000359577
ENST00000404542 ENSP00000384384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030305 heparanase activity
GO:0043169 cation binding
GO:0043395 heparan sulfate proteoglycan binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006027 glycosaminoglycan catabolic process
GO:0008150 biological_process
GO:0030203 glycosaminoglycan metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
HS-GAG degradation pathway
KEGG
Metabolic pathways pathway
Glycosaminoglycan degradation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8WWQ2
TrEMBL
UniProt Splice Variant
Entrez Gene 60495
UniGene Hs.500750
RefSeq NM_001166244 NM_001166245 NM_001166246 NM_021828
HUGO 18374
OMIM 613469
CCDS CCDS53566 CCDS53567 CCDS53568 CCDS7477
HPRD 13669
IMGT
EMBL AF282885 AF282886 AF282887 AJ299719 AJ299720 AL139243 AL356220 AL356268 AL445251 AL590036
GenPept AAG23421 AAG23422 AAG23423 CAC82491 CAC82492 CAH70448 CAH70449 CAH70450 CAH73137 CAH73138 CAH73139 CAI14146 CAI14147 CAI14148 CAI16472 CAI16473 CAI16474 CAI17160 CAI17161 CAI17162
ImmGen HPSE2 (murine)
RNA Seq Atlas 60495