Version 5.4
Homo sapiens Gene: COX15
Summary
InnateDB Gene IDBG-86103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX15
Gene Name cytochrome c oxidase assembly homolog 15 (yeast)
Synonyms CEMCOX2
Species Homo sapiens
Ensembl Gene ENSG00000014919
Encoded Proteins
IDBP-86105
COX15 homolog, cytochrome c oxidase assembly protein (yeast)
IDBP-86107
COX15 homolog, cytochrome c oxidase assembly protein (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3\' region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:99711844-99732100
Strand Reverse strand
Band q24.2
Transcripts
ENST00000370483 ENSP00000359514
ENST00000016171 ENSP00000016171
ENST00000497381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004129 cytochrome-c oxidase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
GO:0006778 porphyrin-containing compound metabolic process
GO:0006783 heme biosynthetic process
GO:0006784 heme a biosynthetic process
GO:0007585 respiratory gaseous exchange
GO:0008535 respiratory chain complex IV assembly
GO:0044281 small molecule metabolic process
GO:0045333 cellular respiration
GO:0055114 oxidation-reduction process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respiratory chain
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040018
View Gene Order
ENSBTAG00000045703
Not yet available
Pathways
NETPATH
REACTOME
REACT_9465
Heme biosynthesis pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00190
Oxidative phosphorylation pathway
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.28326 Hs.718750
RefSeq NM_004376 NM_078470
HUGO
OMIM
CCDS CCDS7481 CCDS7482
HPRD 04707
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca