InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EEF1A2

Summary

InnateDB Gene

IDBG-86175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EEF1A2

Gene Name

eukaryotic translation elongation factor 1 alpha 2

Synonyms

EEF1AL; EF-1-alpha-2; EF1A; HS1; STN; STNL

Species

Homo sapiens

Ensembl Gene

ENSG00000101210

Encoded Proteins

IDBP-86177

eukaryotic translation elongation factor 1 alpha 2

IDBP-86179

eukaryotic translation elongation factor 1 alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:63488013-63499315

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000217182	ENSP00000217182
ENST00000298049	ENSP00000298049

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008135	translation factor activity, nucleic acid binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006414	translational elongation
GO:0010035	response to inorganic substance
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005853	eukaryotic translation elongation factor 1 complex
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000016349

View Gene Order

ENSBTAG00000021685

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_1477

Eukaryotic Translation Elongation pathway

REACT_1014

Translation pathway

REACT_17015

Metabolism of proteins pathway

REACT_71

Gene Expression pathway

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

Cross-References

SwissProt

Q05639

TrEMBL

UniProt Splice Variant

Entrez Gene

1917

UniGene

Hs.433839

RefSeq

NM_001958

HUGO

HGNC:3192

OMIM

602959

CCDS

CCDS13522

HPRD

04265

IMGT

EMBL

AB451389 AF163763 AL121829 BC000432 BC110409 CH471077 L10340 X70940

GenPept

AAA91835 AAF80488 AAH00432 AAI10410 BAG70203 CAA50280 CAC15522 EAW75260

RNA Seq Atlas

1917