Version 5.4
Homo sapiens Gene: MED20
Summary
InnateDB Gene IDBG-86965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED20
Gene Name mediator complex subunit 20
Synonyms PRO0213; TRFP
Species Homo sapiens
Ensembl Gene ENSG00000124641
Encoded Proteins
IDBP-86967
mediator complex subunit 20
IDBP-241974
mediator complex subunit 20
IDBP-294970
mediator complex subunit 20
IDBP-294969
mediator complex subunit 20
IDBP-378509
mediator complex subunit 20
IDBP-813503
mediator complex subunit 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MED20 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41905354-41921139
Strand Reverse strand
Band p21.1
Transcripts
ENST00000265350 ENSP00000265350
ENST00000394251 ENSP00000377795
ENST00000409312 ENSP00000386816
ENST00000409060 ENSP00000386668
ENST00000434077 ENSP00000403061
ENST00000467535
ENST00000482361
ENST00000613074 ENSP00000484159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
Cellular Component
GO:0005654 nucleoplasm
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000092558
View Gene Order
ENSBTAG00000010100
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.278434
RefSeq NM_004275
HUGO
OMIM
CCDS CCDS4862
HPRD 15638
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca