Homo sapiens Gene: PDGFRL
Summary
InnateDB Gene IDBG-8734.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDGFRL
Gene Name platelet-derived growth factor receptor-like
Synonyms PDGRL; PRLTS
Species Homo sapiens
Ensembl Gene ENSG00000104213
Encoded Proteins
platelet-derived growth factor receptor-like
platelet-derived growth factor receptor-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:17576433-17644071
Strand Forward strand
Band p22
Transcripts
ENST00000251630 ENSP00000251630
ENST00000523248
ENST00000541323 ENSP00000444211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004992 platelet activating factor receptor activity
GO:0005019 platelet-derived growth factor beta-receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008150 biological_process
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q15198
TrEMBL
UniProt Splice Variant
Entrez Gene 5157
UniGene Hs.458573
RefSeq NM_006207
HUGO HGNC:8805
OMIM 604584
CCDS CCDS6003
HPRD 05206
IMGT
EMBL AK289450 BC010927 CH471080 CR541952 D37965
GenPept AAH10927 BAA07179 BAF82139 CAG46750 EAW63811
RNA Seq Atlas 5157