Version 5.4
Homo sapiens Gene: C6orf108
Summary
InnateDB Gene IDBG-87905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C6orf108
Gene Name chromosome 6 open reading frame 108
Synonyms C6orf108; dJ330M21.3; RCL
Species Homo sapiens
Ensembl Gene ENSG00000112667
Encoded Proteins
IDBP-87907
chromosome 6 open reading frame 108
IDBP-242505
chromosome 6 open reading frame 108
IDBP-482421
chromosome 6 open reading frame 108
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43225629-43229484
Strand Reverse strand
Band p21.1
Transcripts
ENST00000230431 ENSP00000230431
ENST00000393987 ENSP00000377556
ENST00000509253 ENSP00000422440
ENST00000505042
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042803 protein homodimerization activity
GO:0050144 nucleoside deoxyribosyltransferase activity
GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity
Biological Process
GO:0008283 cell proliferation
GO:0009116 nucleoside metabolic process
GO:0009117 nucleotide metabolic process
GO:0009159 deoxyribonucleoside monophosphate catabolic process
GO:0030307 positive regulation of cell growth
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040658
View Gene Order
ENSBTAG00000019913
Not yet available
Cross-References
SwissProt O43598
TrEMBL H0Y8X4
UniProt Splice Variant
Entrez Gene 10591
UniGene
RefSeq NM_006443 NM_199184
HUGO HGNC:21218
OMIM
CCDS CCDS43465 CCDS4891
HPRD
IMGT
EMBL AF040105 AL133375 BC011683 BQ052226 CH471081 EU585603
GenPept AAB96766 AAH11683 ACB87500 CAI20205 EAX04166
RNA Seq Atlas 10591

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca