InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACTR1A

Summary

InnateDB Gene

IDBG-88047.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTR1A

Gene Name

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)

Synonyms

ARP1; CTRN1

Species

Homo sapiens

Ensembl Gene

ENSG00000138107

Encoded Proteins

IDBP-88049

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)

IDBP-813592

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60%% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:102479229-102502711

Strand

Reverse strand

Band

q24.32

Transcripts

ENST00000369905	ENSP00000358921
ENST00000470322
ENST00000487599	ENSP00000473334
ENST00000494549
ENST00000481044
ENST00000480947

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	39 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005869	dynactin complex
GO:0005875	microtubule associated complex
GO:0070062	extracellular vesicular exosome