Version 5.4
Homo sapiens Gene: LDOC1
Summary
InnateDB Gene IDBG-88129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDOC1
Gene Name leucine zipper, down-regulated in cancer 1
Synonyms BCUR1; Mar7; Mart7
Species Homo sapiens
Ensembl Gene ENSG00000182195
Encoded Proteins
IDBP-88131
leucine zipper, down-regulated in cancer 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:141175745-141177125
Strand Reverse strand
Band q27.1
Transcripts
ENST00000370526 ENSP00000359557
ENST00000460721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 45 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000057615
View Gene Order
Cross-References
SwissProt O95751
TrEMBL
UniProt Splice Variant
Entrez Gene 23641
UniGene
RefSeq NM_012317
HUGO HGNC:6548
OMIM 300402
CCDS CCDS14672
HPRD
IMGT
EMBL AB019527 AL109799 BC003104 CR457088
GenPept AAH03104 BAA34364 CAC18891 CAG33369
RNA Seq Atlas 23641

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca