Version 5.4
Homo sapiens Gene: SPANXA1
Summary
InnateDB Gene IDBG-88161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPANXA1
Gene Name sperm protein associated with the nucleus, X-linked, family member A1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198021
Encoded Proteins
IDBP-88163
sperm protein associated with the nucleus, X-linked, family member A1
IDBP-811769
sperm protein associated with the nucleus, X-linked, family member A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008] Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:141583674-141698444
Strand Reverse strand
Band q27.2
Transcripts
ENST00000370519 ENSP00000359550
ENST00000615379 ENSP00000484283
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007283 spermatogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9NS26
TrEMBL
UniProt Splice Variant
Entrez Gene 728712
UniGene Hs.711784
RefSeq NM_013453
HUGO HGNC:11218
OMIM 300305 300493
CCDS CCDS14674
HPRD
IMGT
EMBL AF098306 AJ457794 AL121881 AY920732 AY920733 AY920735 AY920736 AY920738 AY920739 AY920741 AY920742 AY920743 AY920744 AY920745 AY920746 BC069393 BC069816 DQ994201 DQ994202 DQ994203 DQ994204 DQ994205 DQ994206 DQ994207 DQ994208 DQ994209 DQ994210
GenPept AAF28420 AAH69393 AAH69816 AAY16548 AAY16549 AAY16551 AAY16552 AAY16554 AAY16555 AAY16557 AAY16558 AAY16559 AAY16560 AAY16561 AAY16562 ABN68940 ABN68941 ABN68942 ABN68943 ABN68944 ABN68945 ABN68946 ABN68947 ABN68948 ABN68949 CAD19068 CAD29843 CAI42369
RNA Seq Atlas 30014 728712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca