InnateDB Gene
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IDBG-88177.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPANXA2
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Gene Name
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SPANX family, member A2
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Synonyms
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000203926
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008] Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
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Type |
Protein coding
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Genomic Location
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Chromosome X:141589435-141590772
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Strand
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Forward strand
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Band
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q27.2
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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No orthologs found for this gene |
SwissProt
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Q9NS26
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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728712
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UniGene
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Hs.711784
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RefSeq
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NM_145662
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HUGO
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HGNC:14328
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OMIM
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300305
300493
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CCDS
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CCDS44007
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HPRD |
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IMGT
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EMBL
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AF098306
AJ457794
AL121881
AY920732
AY920733
AY920735
AY920736
AY920738
AY920739
AY920741
AY920742
AY920743
AY920744
AY920745
AY920746
BC069393
BC069816
DQ994201
DQ994202
DQ994203
DQ994204
DQ994205
DQ994206
DQ994207
DQ994208
DQ994209
DQ994210
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GenPept
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AAF28420
AAH69393
AAH69816
AAY16548
AAY16549
AAY16551
AAY16552
AAY16554
AAY16555
AAY16557
AAY16558
AAY16559
AAY16560
AAY16561
AAY16562
ABN68940
ABN68941
ABN68942
ABN68943
ABN68944
ABN68945
ABN68946
ABN68947
ABN68948
ABN68949
CAD19068
CAD29843
CAI42369
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RNA Seq Atlas
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30014
728712
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