Version 5.4
Homo sapiens Gene: GLE1
Summary
InnateDB Gene IDBG-88246.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLE1
Gene Name GLE1 RNA export mediator homolog (yeast)
Synonyms GLE1L; hGLE1; LCCS; LCCS1
Species Homo sapiens
Ensembl Gene ENSG00000119392
Encoded Proteins
IDBP-88248
GLE1 RNA export mediator homolog (yeast)
IDBP-88250
GLE1 RNA export mediator homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:128504700-128542288
Strand Forward strand
Band q34.11
Transcripts
ENST00000309971 ENSP00000308622
ENST00000372770 ENSP00000361856
ENST00000494417
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006406 mRNA export from nucleus
GO:0015031 protein transport
GO:0016973 poly(A)+ mRNA export from nucleus
Cellular Component
GO:0005615 extracellular space
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019715
View Gene Order
ENSBTAG00000030566
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.522418 Hs.605284
RefSeq NM_001003722 NM_001499 XM_006717060
HUGO
OMIM
CCDS CCDS35154 CCDS6904
HPRD 04536
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca