Homo sapiens Gene: PPP2R2C

Summary
InnateDB Gene IDBG-8925.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PPP2R2C
Gene Name protein phosphatase 2, regulatory subunit B, gamma
Synonyms B55-GAMMA; IMYPNO; IMYPNO1; PR52; PR55G
Species Homo sapiens
Ensembl Gene ENSG00000074211
Encoded Proteins
IDBP-8927 protein phosphatase 2, regulatory subunit B, gamma
IDBP-8933 protein phosphatase 2, regulatory subunit B, gamma
IDBP-473757 protein phosphatase 2, regulatory subunit B, gamma
IDBP-477666 protein phosphatase 2, regulatory subunit B, gamma
IDBP-473558 protein phosphatase 2, regulatory subunit B, gamma
IDBP-475408 protein phosphatase 2, regulatory subunit B, gamma
Entrez Gene
Summary The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4: 6322305-6565327
Strand Reverse strand
Band p16.1
Transcripts
ENST00000382599  ENSP00000372042
ENST00000335585  ENSP00000335083
ENST00000314348 
ENST00000506140  ENSP00000423649
ENST00000515571  ENSP00000422374
ENST00000507294  ENSP00000425247
ENST00000513943 
ENST00000509917  ENSP00000423650
ENST00000507028 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein‑Protein  22
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000029120 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000020598 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa05142  Chagas disease (American trypanosomiasis)
hsa05160  Hepatitis C
hsa03015  MRNA surveillance pathway
hsa04530  Tight junction
INOH
INOH website GPCR Dopamine D1like receptor signaling pathway
INOH website Insulin receptor signaling
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y2T4 
TrEMBL D6R943
UniProt Splice Variant
Entrez Gene 5522 
UniGene Hs.479069 Hs.598423
RefSeq NM_001206994  NM_001206995  NM_001206996  NM_181876 
HUGO 9306 
OMIM 605997
CCDS CCDS3388  CCDS56304  CCDS56305 
HPRD 09345
IMGT
EMBL AC093323 AC114815 AC116317 AC122939 AF086924 AF145027 AH007514 AK093115 AK296474 AK316003 BC032954 CH471131
GenPept AAD20987  AAG39636  AAH32954  AAP97279  BAG52658  BAH12367  BAH14374  EAW82393  EAW82394  EAW82395 
ImmGen PPP2R2C (murine) 
RNA Seq Atlas 5522