Homo sapiens Gene: PPP2R2C
Summary
InnateDB Gene IDBG-8925.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PPP2R2C
Gene Name protein phosphatase 2, regulatory subunit B, gamma
Synonyms B55-GAMMA; IMYPNO; IMYPNO1; PR52; PR55G;
Species Homo sapiens
Ensembl Gene ENSG00000074211
Encoded Proteins
protein phosphatase 2, regulatory subunit B, gamma
protein phosphatase 2, regulatory subunit B, gamma
protein phosphatase 2, regulatory subunit B, gamma
protein phosphatase 2, regulatory subunit B, gamma
protein phosphatase 2, regulatory subunit B, gamma
protein phosphatase 2, regulatory subunit B, gamma
Protein Structure
Entrez Gene
Summary The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:6322305-6565327
Strand Reverse strand
Band p16.1
Transcripts
ENST00000382599 ENSP00000372042
ENST00000335585 ENSP00000335083
ENST00000314348
ENST00000506140 ENSP00000423649
ENST00000515571 ENSP00000422374
ENST00000507294 ENSP00000425247
ENST00000513943
ENST00000509917 ENSP00000423650
ENST00000507028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Chagas disease (American trypanosomiasis) pathway
MRNA surveillance pathway pathway
Tight junction pathway
Hepatitis C pathway
INOH
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y2T4
TrEMBL D6R943
UniProt Splice Variant
Entrez Gene 5522
UniGene Hs.479069 Hs.598423
RefSeq NM_001206994 NM_001206995 NM_001206996 NM_181876
HUGO 9306
OMIM 605997
CCDS CCDS3388 CCDS56304 CCDS56305
HPRD 09345
IMGT
EMBL AC093323 AC114815 AC116317 AC122939 AF086924 AF145027 AH007514 AK093115 AK296474 AK316003 BC032954 CH471131
GenPept AAD20987 AAG39636 AAH32954 AAP97279 BAG52658 BAH12367 BAH14374 EAW82393 EAW82394 EAW82395
ImmGen PPP2R2C (murine)
RNA Seq Atlas 5522