Version 5.4
Homo sapiens Gene: PNMA3
Summary
InnateDB Gene IDBG-89346.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PNMA3
Gene Name paraneoplastic Ma antigen 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183837
Encoded Proteins
IDBP-382662
paraneoplastic antigen MA3
IDBP-809390
paraneoplastic Ma antigen 3
IDBP-809393
paraneoplastic Ma antigen 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the paraneoplastic antigen MA (PNMA) gene family, whose protein products share homology with retroviral Gag proteins. They are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153056409-153060467
Strand Forward strand
Band q28
Transcripts
ENST00000424805 ENSP00000390576
ENST00000619635 ENSP00000480719
ENST00000593810 ENSP00000469445
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000046287
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 29944
UniGene
RefSeq NM_001282535 NM_013364
HUGO HGNC:18742
OMIM 300675
CCDS CCDS65344 CCDS35435
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 29944

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca