InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BGN

Summary

InnateDB Gene

IDBG-89505.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BGN

Gene Name

biglycan

Synonyms

DSPG1; PG-S1; PGI; SLRR1A

Species

Homo sapiens

Ensembl Gene

ENSG00000182492

Encoded Proteins

IDBP-89507

biglycan

IDBP-382750

biglycan

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24257755

Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1..

Entrez Gene

Summary

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:153494939-153509554

Strand

Forward strand

Band

q28

Transcripts

ENST00000331595	ENSP00000327336
ENST00000431891	ENSP00000402525
ENST00000472615
ENST00000480756
ENST00000492658

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0005975	carbohydrate metabolic process
GO:0008150	biological_process
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005622	intracellular
GO:0005796	Golgi lumen
GO:0009986	cell surface
GO:0030133	transport vesicle
GO:0031012	extracellular matrix
GO:0042383	sarcolemma
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome