Version 5.4
Homo sapiens Gene: APCDD1
Summary
InnateDB Gene IDBG-896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APCDD1
Gene Name adenomatosis polyposis coli down-regulated 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154856
Encoded Proteins
IDBP-898
adenomatosis polyposis coli down-regulated 1
IDBP-363381
adenomatosis polyposis coli down-regulated 1
IDBP-725531
IDBP-811562
adenomatosis polyposis coli down-regulated 1
IDBP-725630
IDBP-727309
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:10454628-10489948
Strand Forward strand
Band p11.22
Transcripts
ENST00000355285 ENSP00000347433
ENST00000423585 ENSP00000404930
ENST00000582723 ENSP00000463110
ENST00000584596 ENSP00000476491
ENST00000578882 ENSP00000463104
ENST00000579685 ENSP00000464649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017147 Wnt-protein binding
Biological Process
GO:0001942 hair follicle development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0043615 astrocyte cell migration
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071847
View Gene Order
ENSBTAG00000005154
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.293274 Hs.702756
RefSeq NM_153000
HUGO
OMIM
CCDS CCDS11849
HPRD 09595
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca