Version 5.4
Homo sapiens Gene: DUSP9
Summary
InnateDB Gene IDBG-89749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP9
Gene Name dual specificity phosphatase 9
Synonyms MKP-4; MKP4
Species Homo sapiens
Ensembl Gene ENSG00000130829
Encoded Proteins
IDBP-89751
dual specificity phosphatase 9
IDBP-89755
dual specificity phosphatase 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153642492-153651326
Strand Forward strand
Band q28
Transcripts
ENST00000370167 ENSP00000359186
ENST00000342782 ENSP00000345853
ENST00000477033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0007254 JNK cascade
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031383
View Gene Order
ENSBTAG00000008319
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q99956
TrEMBL P78512
UniProt Splice Variant
Entrez Gene 1852
UniGene Hs.721355 Hs.743293
RefSeq NM_001395 XM_005274655
HUGO HGNC:3076
OMIM 300134
CCDS CCDS14724
HPRD
IMGT
EMBL CH471172 U52111 U87167 Y08302
GenPept AAB47559 CAA69610 EAW72847 EAW72848 EAW72849
RNA Seq Atlas 1852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca