Version 5.4
| Homo sapiens Gene: GSTA3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-90829.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | GSTA3 | ||||||||||||||||||
| Gene Name | glutathione S-transferase alpha 3 | ||||||||||||||||||
| Synonyms | GSTA3-3; GTA3 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000174156 | ||||||||||||||||||
| Encoded Proteins |
glutathione S-transferase alpha 3
glutathione S-transferase alpha 3
glutathione S-transferase alpha 3
glutathione S-transferase alpha 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:52847910-52909685 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p12.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Glutathione conjugation pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
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| KEGG |
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q16772 | ||||||||||||||||||
| TrEMBL | Q5JW85 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2940 | ||||||||||||||||||
| UniGene | Hs.102484 | ||||||||||||||||||
| RefSeq | NM_000847 XM_006715072 | ||||||||||||||||||
| HUGO | HGNC:4628 | ||||||||||||||||||
| OMIM | 605449 | ||||||||||||||||||
| CCDS | CCDS4947 | ||||||||||||||||||
| HPRD | 07290 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF020919 AF508266 AL121969 BC020619 CH471081 DQ993361 L13270 L13271 L13272 L13273 L13274 L13275 | ||||||||||||||||||
| GenPept | AAA74634 AAD04712 AAH20619 AAM33360 ABI75350 CAC10389 EAX04390 EAX04391 | ||||||||||||||||||
| RNA Seq Atlas | 2940 | ||||||||||||||||||