InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OPN1LW

Summary

InnateDB Gene

IDBG-90873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OPN1LW

Gene Name

opsin 1 (cone pigments), long-wave-sensitive

Synonyms

CBBM; CBP; COD5; RCP; ROP

Species

Homo sapiens

Ensembl Gene

ENSG00000102076

Encoded Proteins

IDBP-90875

opsin 1 (cone pigments), long-wave-sensitive

IDBP-383311

opsin 1 (cone pigments), long-wave-sensitive

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:154144224-154159032

Strand

Forward strand

Band

q28

Transcripts

ENST00000369951	ENSP00000358967
ENST00000442922	ENSP00000402493
ENST00000463296

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0009881	photoreceptor activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0018298	protein-chromophore linkage
GO:0032467	positive regulation of cytokinesis