Homo sapiens Gene: OPN1LW
Summary
InnateDB Gene IDBG-90873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OPN1LW
Gene Name opsin 1 (cone pigments), long-wave-sensitive
Synonyms CBBM; CBP; COD5; RCP; ROP;
Species Homo sapiens
Ensembl Gene ENSG00000102076
Encoded Proteins
opsin 1 (cone pigments), long-wave-sensitive
opsin 1 (cone pigments), long-wave-sensitive
Protein Structure
Entrez Gene
Summary This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154144224-154159032
Strand Forward strand
Band q28
Transcripts
ENST00000369951 ENSP00000358967
ENST00000442922 ENSP00000402493
ENST00000463296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0009881 photoreceptor activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007603 phototransduction, visible light
GO:0018298 protein-chromophore linkage
GO:0032467 positive regulation of cytokinesis
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0042622 photoreceptor outer segment membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
The retinoid cycle in cones (daylight vision) pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Diseases associated with visual transduction pathway
Opsins pathway
Visual phototransduction pathway
Retinoid cycle disease events pathway
GPCR ligand binding pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P04000
TrEMBL
UniProt Splice Variant
Entrez Gene 5956
UniGene Hs.592247
RefSeq NM_020061
HUGO HGNC:9936
OMIM 300822
CCDS CCDS14742
HPRD 02366
IMGT
EMBL M13300 M13301 M13302 M13303 M13304 M13305 Z68193
GenPept AAB59524 CAA92342
ImmGen OPN1LW (murine)
RNA Seq Atlas 5956