Homo sapiens Gene: OPN1LW

Summary
InnateDB Gene IDBG-90873.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol OPN1LW
Gene Name opsin 1 (cone pigments), long-wave-sensitive
Synonyms CBBM; CBP; COD5; RCP; ROP
Species Homo sapiens
Ensembl Gene ENSG00000102076
Encoded Proteins
IDBP-90875 opsin 1 (cone pigments), long-wave-sensitive
IDBP-383311 opsin 1 (cone pigments), long-wave-sensitive
Entrez Gene
Summary This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X: 153409698-153424507
Strand Forward strand
Band q28
Transcripts
ENST00000369951  ENSP00000358967
ENST00000442922  ENSP00000402493
ENST00000463296 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein‑Protein  2
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004930 G-protein coupled receptor activity
GO:0009881 photoreceptor activity
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0018298 protein-chromophore linkage
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral to plasma membrane
GO:0016021 integral to membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_19231 G alpha (i) signalling events
REACT_18426 Opsins
REACT_160130 Retinoid cycle disease events
REACT_160083 The retinoid cycle in cones (daylight vision)
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P04000 
TrEMBL B1B1F0
UniProt Splice Variant
Entrez Gene 5956 
UniGene Hs.592247
RefSeq NM_020061 
HUGO 9936 
OMIM 300822
CCDS CCDS14742 
HPRD 02366
IMGT
EMBL M13300 M13301 M13302 M13303 M13304 M13305 Z68193
GenPept AAB59524  CAA92342  CAM28377 
ImmGen OPN1LW (murine) 
RNA Seq Atlas 5956