InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MTHFD1

Summary

InnateDB Gene

IDBG-9107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTHFD1

Gene Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

Synonyms

MTHFC; MTHFD

Species

Homo sapiens

Ensembl Gene

ENSG00000100714

Encoded Proteins

IDBP-9109

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

IDBP-583253

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

IDBP-807036

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

IDBP-807037

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

IDBP-807050

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

IDBP-807065

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

IDBP-589432

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:64388031-64463457

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000216605	ENSP00000216605
ENST00000545908	ENSP00000438588
ENST00000554739	ENSP00000477359
ENST00000554768	ENSP00000477501
ENST00000555252
ENST00000557539	ENSP00000476468
ENST00000554057
ENST00000553391
ENST00000554677
ENST00000555858
ENST00000556771
ENST00000553405
ENST00000556284
ENST00000557370	ENSP00000477199
ENST00000554353
ENST00000555709	ENSP00000450560

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	54 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004329	formate-tetrahydrofolate ligase activity
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity
GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524	ATP binding

Biological Process

GO:0000105	histidine biosynthetic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009086	methionine biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0035999	tetrahydrofolate interconversion
GO:0044281	small molecule metabolic process
GO:0046655	folic acid metabolic process
GO:0055114	oxidation-reduction process