InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AKAP5

Summary

InnateDB Gene

IDBG-9126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP5

Gene Name

A kinase (PRKA) anchor protein 5

Synonyms

AKAP75; AKAP79; H21

Species

Homo sapiens

Ensembl Gene

ENSG00000179841

Encoded Proteins

IDBP-9128

A kinase (PRKA) anchor protein 5

IDBP-241020

A kinase (PRKA) anchor protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:64465499-64474503

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000320636	ENSP00000315615
ENST00000394718	ENSP00000378207

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008179	adenylate cyclase binding
GO:0051018	protein kinase A binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006605	protein targeting
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0010739	positive regulation of protein kinase A signaling
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion