Version 5.4
Homo sapiens Gene: CLCNKB
Summary
InnateDB Gene IDBG-91382.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCNKB
Gene Name chloride channel, voltage-sensitive Kb
Synonyms ClC-K2; ClC-Kb; CLCKB
Species Homo sapiens
Ensembl Gene ENSG00000184908
Encoded Proteins
IDBP-91384
chloride channel Kb
IDBP-91390
chloride channel Kb
IDBP-371628
chloride channel Kb
IDBP-808220
chloride channel, voltage-sensitive Kb
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:16043736-16057308
Strand Forward strand
Band p36.13
Transcripts
ENST00000375679 ENSP00000364831
ENST00000375667 ENSP00000364819
ENST00000431772 ENSP00000389344
ENST00000619181 ENSP00000483866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0030554 adenyl nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
GO:0006821 chloride transport
GO:0007588 excretion
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04966
Collecting duct acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1188
UniGene
RefSeq NM_000085 NM_001165945 XM_005245733 XM_006710069
HUGO HGNC:2027
OMIM 602023
CCDS CCDS168 CCDS57974
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 1188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca