Version 5.4
Homo sapiens Gene: PADI4
Summary
InnateDB Gene IDBG-91809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PADI4
Gene Name peptidyl arginine deiminase, type IV
Synonyms PAD; PAD4; PADI5; PDI4; PDI5
Species Homo sapiens
Ensembl Gene ENSG00000159339
Encoded Proteins
IDBP-91811
peptidyl arginine deiminase, type IV
IDBP-91813
peptidyl arginine deiminase, type IV
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20733033
[Mus musculus] Padi4 plays a role in chromatin decondensation to form neutrophil extracellular traps (NETs) in an innate immune response to bacterial infection.
Entrez Gene
Summary This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:17308195-17364004
Strand Forward strand
Band p36.13
Transcripts
ENST00000375453 ENSP00000364602
ENST00000375448 ENSP00000364597
ENST00000468945
ENST00000487048
ENST00000467001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016990 arginine deiminase activity
Biological Process
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006464 cellular protein modification process
GO:0016568 chromatin modification
GO:0018101 protein citrullination
GO:0019827 stem cell maintenance
GO:0036413 histone H3-R26 citrullination
GO:0036414 histone citrullination
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025330
View Gene Order
ENSBTAG00000012052
Not yet available
Cross-References
SwissProt Q9UM07
TrEMBL B1AQ67 Q6EVJ1
UniProt Splice Variant
Entrez Gene 23569
UniGene Hs.522969
RefSeq NM_012387
HUGO HGNC:18368
OMIM 605347
CCDS CCDS180
HPRD
IMGT
EMBL AB017919 AC004824 AJ549502 AJ715936 AJ715938 AK290507 AK314839 AL138798 AL590644 BC025718
GenPept AAH25718 BAA84542 BAF83196 BAG37357 CAE47743 CAG30585 CAG30587 CAH73167
RNA Seq Atlas 23569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca